Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?
نویسندگان
چکیده
منابع مشابه
Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?
Progressive accumulation of specific misfolded protein is a defining feature of amyotrophic lateral sclerosis (ALS), similarly seen in Alzheimer disease, Parkinson disease, Huntington disease and Creutzfeldt-Jakob disease. The intercellular transfer of inclusions made of tau, α-synuclein and huntingtin has been demonstrated, revealing the existence of mechanisms reminiscent of those by which pr...
متن کاملPropagation: prion-like mechanisms can explain spreading of motor neuronal death in amyotrophic lateral sclerosis?
Journal of Neurology Neurosurgery & Psychiatry (ISSN No: 0022-3050) is published monthly by BMJ Publishing Group and distributed in the USA by Mercury International Ltd. as mailing agent. Periodicals postage paid at Rahway, NJ. POSTMASTER: send address changes to Journal of Neurology Neurosurgery & Psychiatry, Mercury International Ltd, 365 Blair Road, Avenel, NJ, 07001, USA. Editorial commenta...
متن کاملAn Amyotrophic Lateral Sclerosis Like Symptoms Associated with Lead Toxicity
Abstract Lead is a heavy metal that affects many organs such as nervous system, liver, and kidney. The most important affected organ is central nervous system. The present study reported a case similar to Amyotrophic lateral sclerosis (ALS) due to lead exposure in an opium addicted person. The patient complaint was the weakness of upper and lower limbs in addition to the unsteadiness of gait...
متن کاملMolecular Motor Proteins and Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons in the brain, brainstem and spinal cord, which is characterized by motor dysfunction, muscle dystrophy and progressive paralysis. Both inherited and sporadic forms of ALS share common pathological features, however, the initial trigger of neurodegeneration remains unknown. Motor neurons are uniquely targ...
متن کاملAmyotrophic lateral sclerosis: a dying motor unit?
INTRODUCTION ALS is a late-onset neurodegenerative disease of unknown etiology. Since it was first described (Charcot, 1874), several mechanisms, such as oxidative stress, glutamate excitotoxicity, glial cell pathology, or aberrant RNA metabolism (for review, see Vucic and Kiernan, 2009). Recently the evidence accumulates that mitochondrial damage and defective axonal transport may play a pivot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2012
ISSN: 0022-3050,1468-330X
DOI: 10.1136/jnnp-2011-301826